Friday, November 9, 2012

The future is here


This latest review on MicroRNAs points out how they may serve as early detectors of disease; this in turn suggests that when used as biomarkers, MicroNRAs may help eradicate many forms of cancer via early (and non-invasive) detection, and not just in smokers. It's a good thing that we have tobacco scientists. While everyone else seems to be pushing evermore towards the failed ideas of prohibition and scientific McCarthyism, there appear to be some brilliant minds that have chosen to push ahead into the future instead:

A research review by scientists at British American Tobacco suggests that the regulatory functions and inherent stability of microRNAs make them suitable biomarker candidates for early detection of the molecular and genetic changes associated with smoking-related diseases (Biomarkers Med. (2012) 6(5), 671–684).

‘MicroRNAs (miRNAs) are non-coding RNA molecules that play key roles in regulating gene expression,’ according to a BAT press note issued yesterday. ‘They are involved in a wide range of biological processes such as cell cycle control, apoptosis and several developmental and physiological processes.

This in particular caught my attention:

‘Research shows that cigarette smoke impairs the regulatory function of a variety of miRNAs in all stages of lung cancer formation, but that resulting changes in miRNA expression only become irreversible after exposure to high doses of smoke for some time.’

I take this to mean that if caught early enough, the onset of lung cancer can be REVERSED!

I even harbor the radical notion that someday (hopefully sooner, rather than later) we  smokers will have the option of choosing between several reduced risk (with risk reductions upwards of 70-90%) cigarettes. Early detection, coupled with the proliferation and marketing of reduced risk products may well serve to save millions of lives in the near future.

Of course, there will be the usual detractors who have been shouting from the mountain tops for the last 40+ years about how total abstinence provides the only one way ticket to health. Those same people also predicted a smoke-free world by the year 2000.

It's time to start behaving like we're in the 21st century, one that is rooted in real solutions for a real world devoid of unicorns and fairies.  There will be no room for plain packaging in such a scenario, for we smokers will need to become more informed (rather than less) if we are to make better choices for our health.


BAT identifies promising biomarkers of smoking-related disease and prognosis : Tobacco Reporter

8 comments:

  1. They fail to state at what age these supposed bio-markers were detectable and what age does to lowered immune response in association to these changes besides concentrations of smoke.

    Cancer is pretty much a disease of the aged especially where smoking is concerned and the effects of age related immune response cannot be dismissed as smoke caused this effect........when it doesnt in younger people exposed to the same amounts of smoke.....The key is enhansing immune systems to be comparable to that of the young....there in lies the cure to most age related diseases instead of blaming concentrations of smoke.

    ReplyDelete
    Replies
    1. This comment has been removed by the author.

      Delete
    2. Harley-

      "Cancer is pretty much a disease of the aged.."

      True, but not always. Some people have a genetic predisposition to lung cancer (and other diseases). In those who harbor a genetic predisposition to lung cancer, active smoking (beyond certain thresholds) CAN act as a catalyst; it may not be the ONLY cause, but it is certainly part of the equation. ....and then you have those people who smoke like chimneys (ie., over a pack a day, etc..). That's quite obviously asking for trouble, don't you think? Chain smokers with a genetic predisposition for cancer would be the first in line to benefit from early detection, especially if such early detection can REVERSE the trajectory of the mutated cells.

      "The key is enhansing immune systems to be comparable to that of the young.."

      Of course. No one would argue with that. But what happens if we are able to enhance the immune systems of the aged while at the same time reducing the carcinogenic nature of smoking? Then we'd be talking about some serious life extension..lol..But then we'd run into issues of overcrowding and overpopulation.

      Delete
    3. ..and I am not implying that I believe that those with impeccable genes are totally out of the water (those some appear to be) when it comes to smoking and risk. Too much of anything is bad.

      Delete
  2. The changing profile of miRNA expression in diseased and normal tissues, the dysregulation of a variety of miRNAs throughout all stages of pulmonary carcinogenesis by cigarette smoke, non-invasive sampling methods and the reversibility of miRNA expression on smoking cessation reported indicate the relevance of miRNAs as potentially ideal biomarkers of biological effect,” said the review author, BAT’s Anisha Banerjee.

    The researchers note that further studies are required to identify the miRNAs most relevant to specific diseases and to develop robust isolation and detection methods.

    smoking cessation

    the reversibility of miRNA expression on smoking cessation reported indicate the relevance of miRNAs ..........Jred it sounds like he got bought off by Big Pharma or smokefree........the ending is identical to any second hand smoke junk study done! practically verbatum. No I wouldnt put it passed BAT to succumb to big pharmas preaching and he governments pushing for them to admit smoking causes disease.......You have to remember the RICO case forced BAT to make statements thru Judge Kesslers court and this I think is predicated upon that court ruling in an about face move. I think Big Pharma said do it this way so it will have force of a study find!

    ReplyDelete
    Replies
    1. ".Jred it sounds like he got bought off by Big Pharma or smokefree......."

      Hmmm...maybe...maybe not.

      What would happen if they (the scientists) could prove that such biomarkers found in current users of a reduced risk tobacco product(s) have returned to that of a former or never smoker? How would the anti-smokers be able to refute the existence of a reduced risk product if this were to occur in future studies? Doesn't this study in fact act as a precedent in proving that such a scenario is possible?


      "..the ending is identical to any second hand smoke junk study done! practically verbatum."

      How so?

      Delete
  3. reversibility of miRNA expression on smoking cessation reported indicate the relevance of miRNAs as potentially ideal biomarkers of biological effect..................

    Jred it appears just about anything can disrupt miRNA in humans and I mean about anything!
    Especially when we see Big Tobacco all of a sudden come out with an agreement with TC we have to totally question the motives behind it. The second they stated/smoking cessation makes it disapear my warning radar kicked in......

    Heres a list from google alone:

    Croce - Cited by 599

    Search ResultsDisrupted microRNA expression caused by Mecp2 loss in a mouse ...www.ncbi.nlm.nih.gov/pubmed/20716963Similar
    You +1'd this publicly. Undo
    by RG Urdinguio - 2010 - Cited by 23 - Related articles
    Oct 1, 2010 – Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome. Urdinguio RG, Fernandez AF, Lopez-Nieva P, ...
    Changes in microRNA expression in rat lungs caused by ...www.ncbi.nlm.nih.gov/pubmed/23124245You +1'd this publicly. Undo
    by S Tanaka - 2012
    Biomed Res. 2012;33(5):255-63. Changes in microRNA expression in rat lungs caused by sevoflurane anesthesia: a TaqMan® low-density array study. Tanaka ...
    BMC Genomics | Full text | Altered microRNA expression in ...www.biomedcentral.com/1471-2164/12/527Cached
    You +1'd this publicly. Undo
    by J Kocerha - 2011 - Cited by 5 - Related articles
    Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations. Jannet Kocerha†, Naomi Kouri†, ...
    PLOS Genetics: MicroRNA Expression and Regulation in Human ...www.plosgenetics.org/.../info%3Adoi%2F10.1371%2Fjournal.pgen....Cached
    You +1'd this publicly. Undo
    by HY Hu - 2011 - Cited by 13 - Related articles
    Oct 13, 2011 – Furthermore, we find indications that some of the human-specific gene expression profiles caused by miRNA expression divergence might be ...
    Sustained expression of microRNA-155 in hematopoietic stem cells ...jem.rupress.org › 2008 Archive › 17 MarchYou +1'd this publicly. Undo
    by RM O'Connell - 2008 - Cited by 283 - Related articles
    Feb 25, 2008 – Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. Ryan M. O'Connell 1 ,; Dinesh S. Rao ...
    Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression andwww.hindawi.com/journals/pm/2012/791234/Cached
    You +1'd this publicly. Undo
    by R Russ - 2011 - Cited by 3 - Related articles
    Oct 19, 2011 – Cigarette smoke may also cause dysregulation by affecting regulatory mechanisms controlling miRNA expression. Researchers have shown a ...
    PhenomiR: a knowledgebase for microRNA expression in diseases ...genomebiology.com/content/11/1/R6Cached
    You +1'd this publicly. Undo
    by A Ruepp - 2010 - Cited by 36 - Related articles
    However, the potential of deregulated miRNA expression to cause severe impairments has already been demonstrated in the early days of microRNA research ...
    Differential Patterns of MicroRNA Expression in Neuroblastoma Are ...cancerres.aacrjournals.org/content/67/3/976.abstractYou +1'd this publicly. Undo
    by Y Chen - 2007 - Cited by 178 - Related articles
    Feb 1, 2007 – We also show that small interfering RNA inhibition of MYCN by itself causes similar alterations in the expression of miRNA loci. In vitro ...
    Downregulation of microRNA expression in the lungs of rats ...www.fasebj.org/content/23/3/806.fullYou +1'd this publicly. Undo
    by A Izzotti - 2009 - Cited by 125 - Related articles
    The results obtained provide evidence that exposure of rats to ECS causes extensive alterations in miRNA expression in the lung. In the interpretation of these ...
    PLOS ONE: Dynamic Changes in the MicroRNA Expression Profile ...www.plosone.org/.../info%3Adoi%2F10.1371%2Fjournal.pone.0017...Cached
    You +1'd this publicly. Undo
    by D von Schack - 2011 - Cited by 6 - Related articles
    A better understanding of the molecular mechanisms responsible for causing these ... We performed a miRNA expression profiling study of dorsal root ganglion ...

    ReplyDelete
    Replies
    1. Harley,

      "The second they stated/smoking cessation makes it disapear my warning radar kicked in......"

      Ok, I see your point but, you still haven't answered my question:

      "But what happens if we are able to enhance the immune systems of the aged while at the same time reducing the carcinogenic nature of smoking?"

      Delete

Share It